- BMSystems will participate to BIO in Boston, June 18-21; and Bio-Europe in Hamburg November, 12-14.
- Munich,may 11-12, 2012: BMSystems' CSO François Iris, is invited as session chairman to the 8th International Workshop on Computational Neuropsychiatry: Sleep, Affective disorders and Schizophrenia - An integrated view.
- Press-Release-Feb-2012: Pherecydes Pharma secures a €1.2-million Defense agency funding for evaluating the use of bacteriophages against infected, antibiotic resistant burns.
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BMSystems European Commission Conference Presentation
The EC "From Systems Biology to Systems Medicine" report
Industrial biotech World cluster
Spin-off sites
CADI*™ Research - description
The Life science modeling dilemma
- The mechanisms of life are complex, non-linear and integrative
- In “complex living" systems , the functions of biological components and mechanisms are event and context-dependent.
- Classical “Cartesian” modeling approaches, valid for the majority of man-made artifacts, imply the concept of a “blue-print”.
- But this concept is at the opposite of biological reality...
- While “Cartesian” Bioinformatics and Mathematical tools have proven to be efficient to collect, structure, analyze, simulate specific functions to test or to generate innovative hypotheses, yet...
- The “garbage in, garbage out” reality, tells us that the information produced and published (even in leading scientific journals) is necessarily ALWAYS incomplete, biased and erroneous to unknown extents.
- Despite increasing investments in Technology & I.T., major drugs products submissions to FDA are constantly declining.
The CADI*™ answer: Heuristic Predictive Integrative Biology or Heuristic Systems Biology:
- The CADI™ (Computer Assisted Deductive Integration) proprietary modeling approach is the most efficient synergic process linking organic non-linear integration (Brain intelligence) and in-silico data processing power (collecting, structuring and manipulating data) to build validated biological interaction maps. CADI ™ is based on the negative selection process invented by Dr. François Iris, founder, Chairman and CSO of the company.
- The CADI™ models, belong to the non-mathematical holistic and heuristic class of models. They can describe the dynamics of a pathological process and/or the pathological mechanisms vs. control. They are surely not exact maps of the complex reality, but they are pertinent representations that gather the minimum knowledge and intelligence necessary to allow researchers to take the best possible decisions for the best possible results.
CADI™ : The first “heuristic” modeling approach, successfully applying its 5 principles
- “Architectural Principles” Approach;
- “Negative Selection” Process;
- “4 steps validation” Process;
- Broad life sciences & IT Expertise;
- “Synergic collaboration” with classical IT partners.
The second generation tools, CADI™ Process, development started in 2002
The unique CADI™ 4 steps validation process
The CADI™ 4 steps validation process starts when the integrative biology researchers generate the initial CADI™ model
The initial CADI™ Ver.0 model is constructed by "integrative biology" researchers.
- Step 1: For each loop, "integrative biology" researchers integrate the experimental results to generate the next CADI™ Ver. n+1 model .
- Step 2: CADI™ model forecasts are defined by both experimental and integrative biology researchers The "experimental biology" researchers define and/or invent new innovative experimentations to test the models forecasts.
- Step 3: "Experimental biology" researchers implement the innovative experimental approaches to test the model forecasts.
- Step 4: Experimental results are analyzed and interpreted by both experimental and integrative biology researchers.
The CADI™ 4 steps validation process stops when no key unexpected results are reported.
The first generation (abandoned in 2001): Bio-Graph™ (1998-2001)
- This initial "Cartesian" integrative plate-form, called "Bio-Graph™" because largely based upon graph theories, was developed over the period 1998-2001
- This technology allowed the production of the first biological models of complex human pathologies ever produced (Tamoxifen resistance, partly with the CADI™ prototype)
- However, this approach was extremely limited on several fronts:
- It required that all the papers be annotated before use, etc...
- It required massive amounts of human intervention at all stages of the analytical process and,
- while allowing to efficiently analyze at the cellular level, it was woefully inadequate for tasks where different tissues or organs had to be taken into consideration.